Murley previously player for England at U18 and U20s level while Sinckler, who missed England's summer tour because of a back issue, returns to the international set-up alongside Max Malins, Val Rapava Ruskin and Raffi Quirke.

Henry Slade has been left out by head coach Eddie Jones, as well as fellow backs Danny Care and Joe Marchant.

England will play Argentina in the first of their four matches at Twickenham Stadium on Sunday, November 6. They will then host Japan, followed by New Zealand and South Africa.

England squad

Forwards: Alex Coles, Luke Cowan-Dickie, Tom Curry, Ellis Genge, Joe Heyes, Jonny Hill, Maro Itoje, Courtney Lawes, Lewis Ludlam, George McGuigan, Val Rapava Ruskin, David Ribbans, Bevan Rod, Sam Simmonds, Kyle Sinckler, Jack Singleton, Hugh Tizard, Billy Vunipola, Mako Vunipola and Jack Willis.

Backs: Henry Arundell, Joe Cokanasiga, Owen Farrell, George Furbank, Will Joseph, Max Malins, Jonny May, Cadan Murley, Jack Nowell, Guy Porter, Raffi Quirke, Marcus Smith, Freddie Steward, Manu Tuilagi, Jack van Poortvliet and Ben Youngs.

Unavailable for selection due to injury: Alfie Barbeary, Ollie Chessum, Nic Dolly, Alex Dombrandt, Charlie Ewels, Tommy Freeman, George Ford, Jamie George, Sam Jeffries, Nick Isiekwe, Harry Randall, Will Stuart, Sam Underhill and Jack Walker.

More to follow...

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