Her parents, Dean Gregory and Claire Staniforth, had fought to overturn multiple court rulings on their daughter's treatment, but were not successful.

Indi, who was born with a rare genetic condition, had been transferred from the Queen's Medical Centre in Nottingham to a hospice on Sunday when her life support was withdrawn.

Mr Gregory said: "Indi's life ended at 01.45am. Claire and I are angry, heartbroken and ashamed.

"The NHS and the courts not only took away her chance to live a longer life, but they also took away Indi's dignity to pass away in the family home where she belonged.

"They did succeed in taking Indi's body and dignity, but they can never take her soul.

"They tried to get rid of Indi without anybody knowing, but we made sure she would be remembered forever. I knew she was special from the day she was born.

"Claire held her for her final breaths."

Indi was born in February with a rare mitochondrial disease that saps energy, and had been receiving life-sustaining treatment.

Her doctors said she was suffering from significant pain and distress, and that treatment was futile.

Baby Indi's move to the hospice came after the Court of Appeal dismissed a challenge from her parents on Friday to an earlier High Court ruling that her life support should be removed in either a hospital or a hospice.

High Court judge Mr Justice Peel had ruled limiting treatment would be lawful, and doing so would be in Indi's best interests.

Her parents, who are from from Ilkeston, Derbyshire, had said she should be allowed to have treatment removed at home.

They also failed in a bid to transfer Indi to a hospital in Rome where she had been offered treatment and Italian citizenship.

Nottingham University Hospitals NHS Trust said in a statement: "We are all deeply saddened by the death of Indi and wish to express our heartfelt condolences to her family at this terribly difficult time.

"This has been a very long and challenging journey for Indi, her parents and everyone involved and we will all be holding them in our thoughts."

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Andrea Williams, chief executive of the Christian Legal Centre, said: "Our hearts are broken for Dean and Claire and their family. Please hold them in your prayers at this time.

"At the Christian Legal Centre, we have given our all, working day and night to support Indi's parents in their weeks, days and hours of need as they sought to protect their daughter and pursue justice.

"We have also worked to make known how important it is to uphold laws that wholly protect life and the rights of parents in the lives of their children. Doctors cannot be compelled to treat a patient against their conscience, but neither should they be the ones to prevent parents who secure specialist medical treatment for their child elsewhere from accessing that help.

"Justice is done in the light and a truly compassionate society protects its most vulnerable."